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Clinical Trials

Parasol Dry AMD/Geographic Atrophy  (81201887MDG2001)  [Enrollment Open]

Phase 2b, Randomized, Double-masked, Multicenter, Dose-ranging, Sham-controlled Clinical Trial To Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

Gather2 ISEE2008 –  Iveric Bio [Enrollment Closed]

A Phase 3, multicenter, randomized, double-masked shamcontrolled clinical trial to assess the safety and efficacy of intravitreal administration of Zimura (complement C5 inhibitor) in patients with Geographic Atrophy secondary to Age-Related Macular Degeneration

Atmosphere – RGX-314-2104 – REGENXBIO  [Upcoming Trial]

A Randomized, Partially Masked, Controlled, Phase 2b/3 Clinical Study to Evaluate the Efficacy and Safety of RGX-314 Gene Therapy in Participants with nAMD

Shore – OPT-302-1004 – OPTHEA  [Upcoming Trial]

A Phase 3, Multicentre, Double-masked, Randomised Study to Evaluate the Efficacy and Safety of Intravitreal OPT-302 in Combination with Ranibizumab, Compared with Ranibizumab Alone, in Participants with Neovascular Age-related Macular Degeneration (nAMD)

EYE103-101 DME & Wet AMD  [Upcoming Trial]

 A 2-part study consisting of an open-label multiple ascending dose (MAD) safety study, and a dose-finding single-masked comparative safety and preliminary efficacy study of intravitreal (IVT) EYE103 in a mixed population of participants with diabetic macular edema (DME) and neovascular age-related macular degeneration (NVAMD)

Dream Diabetic Retinopathy (OTT166-201)  [Enrollment Closed]

A Phase 2 Randomized, Double-Masked, Vehicle-Controlled, Multicenter Study to Evaluate the Safety and Efficacy of OTT166 Ophthalmic Solution in the Treatment of Diabetic Retinopathy (DR)

TENAYA – GR40306 – Genentech Roche [Trial Completed]

A Phase III, multicenter, randomized, double-masked, active comparator controlled study to evaluate the efficacy and safety faricimab in patients with neovascular age-related macular degeneration. 

Pavilion GR41675 – Genentech – Roche [Enrollment Closed]

A Phase III, Multicenter, Randomized study of the efficacy, safety, and pharmacokinetics of the Port Delivery System with Ranizumab in patients with Diabetic Retinopathy

Condor: CRTH258D2301 – Novartis [Enrollment Closed]

Novartis pharmaceuticals trail entitled: A 96-week, two-arm, randomized single-masked, multi-center, Phase III study assessing the efficacy and safety of Brolucizumab 6mg compared to Panretinal Photocoagulation Laser in patients with Proliferative Diabetic Retinopathy.

Balaton – GR41984 – Genentech – Roche [Enrollment Closed]

A Phase III, Multicenter, Randomized, Double-Masked, Active comparator – controlled study to evaluate the efficacy and safety of Faricimab in patients with Macular Edema secondary to Branch Retinal Vein Occlusion 

Rivoli CRVO BP44241 [Upcoming Trial]

A phase IB, Multicenter, Randomized, Double Masked, Active Comparator-Controlled Study to investigate the biological activity, safety, tolerability, pharmacokinetics and pharmacodynamics of ro7200394 in participants with macular edema secondary to central retinal vein occlusion

Comino- GR41986  – Genentech – Roche [Enrollment Closed]

A Phase III, Multicenter, Randomized, Double-Masked, Active comparator controlled study to evaluate the efficacy and safety of Faricimab in patients with Macular Edema secondary to Central Retinal or Hemiretinal Vein Occlusion.

EYE103-101 DME & Wet AMD [Upcoming Trial]

 A 2-part study consisting of an open-label multiple ascending dose (MAD) safety study, and a dose-finding single-masked comparative safety and preliminary efficacy study of intravitreal (IVT) EYE103 in a mixed population of participants with diabetic macular edema (DME) and neovascular age-related macular degeneration (NVAMD)

Protocol GR43828 (DME Study) [Enrollment Open]

A Phase I, Multicenter, Open-label study of the safety, tolerability, pharmacokinetics, and immunogenicity of intravitreal injections of RO7446603 alone and co-administered with aflibercept in patients with Diabetic Macular Edema.

Elevatum- Genentech Roche [Enrollment Open]

A Phase IIIB/IV, Multicenter, Open-label, Single-arm study to investigate Faricimab (ro6867461) treatment response in treatment-naïve, underrepresented patients with diabetic macular edema.

Pagoda GR40550 – Genentech Roche [Enrollment Closed] 

A Phase III, Multicenter, Randomized, visual assessor masked, active comparator study of the efficacy, safety, and pharmacokinetics of the port delivery system with Ranibizumab in patients with Diabetic Macular Edema.   

Rhone-X GR41987 – Genentech – Roche [Enrollment Closed]

A Multicenter, open-Label extension study to evaluate the long-term safety and tolerability of Faricimab in patients with Diabetic Macular Edema.

YOSEMITE – GR40349- Genentech Roche [Trial Completed]

A Phase III, multicenter, randomized, double-masked, active comparator controlled study to evaluate the efficacy and safety of RO6867461 in patients with diabetic macular edema.

COOL-3 – RecensMedical Inc [Trial Completed]

A Randomized, Masked, Controlled Trial Studying the Use of Rapid Cooling Anesthesia for Local Anesthesia among Patients Receiving Intravitreal Injections. 

  • Diabetic Retinopathy in HIV Subjects Treated with EGRIFTA
  • Treatment for center-involved DME in Eyes with Very Good Visual Acuity
  • Short-term Evaluation of Combination Corticosteroid + Anti-VEGF Treatment for Persistent Central-involved Diabetic Macular Edema Following Anti-VEGF Therapy in Pseudophakic Eyes
  • Lucentis – Avastin Trial Design
  • Protocol “L”: Evaluation of Visual Acuity Measurements in Eyes with Diabetic Macular Edema
  • Protocol “N”: An Evaluation of Intravitreal Ranibizumab for Vitreous Hemorrhage due to Proliferative Diabetic Retinopathy
  • Mild Macular Grid (MMG) for Diabetic Macular Edema
  • Steroid Injection for Diabetic Macular Edema
  • Vitrectomy for Diabetic Macular Edema
  • Peribulbar Triamcinolone
  • PRP for Diabetic Macular Edema
  • Subclinical Diabetic Macular Edema
  • Anecortave Acetate for Wet AMD
  • Anecortave Acetate for Dry AMD
  • Surgical Therapeutics for Epiretinal Membranes and Vitrectomy
  • Branch Vein Occlusion Sheathotomy Study
  • Vit 100 (VitrenAse) Study for PVR
  • Oral treatment of Diabetic Retinopathy (Lilly)
  • Photodynamic Therapy (PDT) Study – Approved by FDA 4/2000
  • Macular Translocation for CNV
  • Perfluoron (PFO) Phase IV Clinical Trial
  • Submacular Surgery Pilot Trials (SST)
  • Perfluoron Study (PFO)
  • Syntex Ganciclovir Implant Trials
  • ISIS CMV Retinitis Trials
  • RPE Transplantation Study
  • Collaborative Ocular Melanoma
  • COMS
  • Macular Photocoagulation Study (MPS)
  • IOP Vitrectomy Study
  • Age-Related Eye Disease Study
  • Richard-James Silicone Oil Study
  • Vitrectomy for Macular Hole Study
  • Endophthalmitis Vitrectomy Study (EVS)
  • Advanced ROP Study
  • SCORE2 – NIH (National Eye Institute)  2014 – 2016