Clinical Trials

 

Current Trials

Our retina specialists and fellows are involved in many clinical trials to continue advancing technology and techniques related to this area of medicine 

RHONE-X (Yosemite Extension Study) GR40349 – Genentech - Roche 

A Phase 3B, multicenter extension study of Diabetic Macular Edema.

 

CONDOR CRTH258D2301 – Novartis 

A Phase 3, multicenter, randomized, masked study evaluating the efficacy of Brolucizumab in treatment of Proliferative Diabetic Retinopathy.

 

BALATON GR41984 BRVO / Comino GR41986 CRVO – Genentech - Roche 

A Phase 3, multicenter, randomized, masked study evaluating the efficacy of Faricizumab in treatment of Branch Retinal Vein Occlusion and Central Retinal Vein Occlusion with Macular Edema.

 

PAGODA – Genentech - Roche 

A Phase 3, multicenter, study evaluating the efficacy of the long-acting sustained drug Port Delivery System for the treatment of Diabetic Macular Edema.

 

PAVILION – Genentech - Roche 

A Phase 3, multicenter, study evaluating the efficacy of the long-acting sustained drug Port Delivery System for the treatment of severe Diabetic Retinopathy. (Enrollment starting in 2021)

 

YOSEMITE GR40349 – Genentech - Roche 

A Phase III, Multicenter, Randomized, Double-Masked, active comparator controlled study to evaluate the efficacy and safety of RO6867461 in patients with diabetic macular edema.

 

TENAYA  GR40306 – Genentech - Roche

A Phase III, Multicenter, Randomized, Double-Masked, active comparator controlled study to evaluate the efficacy and safety of FARICIMAB in patients with neovascular age related macular degeneration.

 

RAVEN – CRTH258C2302  Novartis

An Eighteen-Month, Two-Arm, Randomized, Double-Masked, Multicenter, Phase III Study Assessing the Efficacy and Safety of Brolucizumab versus Aflibercept in Adult Patients with Visual Impairment due to Macular Edema secondary to Central Retinal Vein Occlusion.

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Eye Test

Completed Trials

 HAWK - RTH258-C001   Alcon Research Ltd.

Two-Year, Randomized, Double-Masked, Multicenter, Three-Arm Study Comparing the Efficacy and Safety of RTH258 versus Aflibercept in Subjects with Neovascular Age-Related Macular Degeneration 2015-2018

 

CEDAR/SEQUIOA - AGN150998-005/006 - Allergan

Safety and Efficacy of Abicipar Pegol in Patients with Neovascular Age-related Macular Degeneration- 2016-2019

  

AERPIO - Trialrunners AKB - 9778 CI 5001 

Phase 2 Double-masked, Placebo-controlled Study To Assess The Safety And Efficacy Of Subcutaneously Administered AKB 9778 15mg Once Daily Or 15mg Twice Daily For 12 Months In Patients With Moderate To Severe Non-Proliferative Diabetic Retinopathy - 2017-2019

 

SCORE2 - NIH (National Eye Institute)     2014 – 2016

 Study of Comparative Treatments for Retinal Vein Occlusion 2 [SCORE2]: a multicenter, prospective, randomized non-inferiority trial of eyes with macular edema secondary to central retinal vein occlusion, comparing intravitreal bevacizumab every 4 weeks with intravitreal aflibercept every 4 weeks. 2014-2016

Other Completed Trials

  • Diabetic Retinopathy in HIV Subjects Treated with EGRIFTA

  • Treatment for center-involved DME in Eyes with Very Good Visual Acuity

  • Short-term Evaluation of Combination Corticosteroid + Anti-VEGF Treatment for Persistent Central-involved Diabetic Macular Edema Following Anti-VEGF Therapy in Pseudophakic Eyes

  • Lucentis – Avastin Trial Design

  • Protocol “L”: Evaluation of Visual Acuity Measurements in Eyes with Diabetic Macular Edema

  • Protocol “N”: An Evaluation of Intravitreal Ranibizumab for Vitreous Hemorrhage due to Proliferative Diabetic Retinopathy

  • Mild Macular Grid (MMG) for Diabetic Macular Edema

  • Steroid Injection for Diabetic Macular Edema

  • Vitrectomy for Diabetic Macular Edema

  • Peribulbar Triamcinolone

  • PRP for Diabetic Macular Edema

  • Subclinical Diabetic Macular Edema

  • Anecortave Acetate for Wet AMD

  • Anecortave Acetate for Dry AMD

  • Surgical Therapeutics for Epiretinal Membranes and Vitrectomy

  • Branch Vein Occlusion Sheathotomy Study

  • Vit 100 (VitrenAse) Study for PVR

  • Oral treatment of Diabetic Retinopathy (Lilly)

  • Photodynamic Therapy (PDT) Study – Approved by FDA 4/2000

  • Macular Translocation for CNV

  • Perfluoron (PFO) Phase IV Clinical Trial

  • Submacular Surgery Pilot Trials (SST)

  • Perfluoron Study (PFO)

  • Syntex Ganciclovir Implant Trials

  • ISIS CMV Retinitis Trials

  • RPE Transplantation Study

  • Collaborative Ocular Melanoma

  • COMS

  • Macular Photocoagulation Study (MPS)

  • IOP Vitrectomy Study

  • Age-Related Eye Disease Study

  • Richard-James Silicone Oil Study

  • Vitrectomy for Macular Hole Study

  • Endophthalmitis Vitrectomy Study (EVS)

  • Advanced ROP Study

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