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Clinical Trials

Publications: Publications

Current Trials

Our retina specialists and fellows are involved in many clinical trials to continue advancing technology and techniques related to this area of medicine 

Phase 1 DME-Genentech Roche [Enrollment Open]

A Phase I, Multicenter, Open-label study of the safety, tolerability, pharmacokinetics, and immunogenicity of intravitreal injections of RO7446603 alone and co-administered with aflibercept in patients with Diabetic Macular Edema.

Elevatum- Genentech Roche [Enrollment Open]

A Phase IIIB/IV, Multicenter, Open-label, Single-arm study to investigate Faricimab (ro6867461) treatment response in treatment-naïve, underrepresented patients with diabetic macular edema

Pagoda GR40550 - Genentech Roche [Enrollment Closed] 

A Phase III, Multicenter, Randomized, visual assessor masked, active comparator study of the efficacy, safety, and pharmacokinetics of the port delivery system with Ranibizumab in patients with Diabetic Macular Edema.   

Pavilion GR41675 – Genentech - Roche [Enrollment Closed]

A Phase III, Multicenter, Randomized study of the efficacy, safety, and pharmacokinetics of the Port Delivery System with Ranizumab in patients with Diabetic Retinopathy

 

Rhone-X GR41987 – Genentech - Roche [Enrollment Closed]

A Multicenter, open-Label extension study to evaluate the long-term safety and tolerability of Faricimab in patients with Diabetic Macular Edema.

Gather2 ISEE2008 –  Iveric Bio [Enrollment Closed]

A Phase 3, multicenter, randomized, double-masked shamcontrolled clinical trial to assess the safety and efficacy of intravitreal administration of Zimura (complement C5 inhibitor) in patients with Geographic Atrophy secondary to Age-Related Macular Degeneration

Condor: CRTH258D2301 – Novartis [Enrollment Closed]

Novartis pharmaceuticals trail entitled: A 96-week, two-arm, randomized single-masked, multi-center, Phase III study assessing the efficacy and safety of Brolucizumab 6mg compared to Panretinal Photocoagulation Laser in patients with Proliferative Diabetic Retinopathy.

 

Balaton – GR41984 - Genentech - Roche [Enrollment Closed]

A Phase III, Multicenter, Randomized, Double-Masked, Active comparator - controlled study to evaluate the efficacy and safety of Faricimab in patients with Macular Edema secondary to Branch Retinal Vein Occlusion 

 

Comino- GR41986  – Genentech - Roche [Enrollment Closed]

A Phase III, Multicenter, Randomized, Double-Masked, Active comparator controlled study to evaluate the efficacy and safety of Faricimab in patients with Macular Edema secondary to Central Retinal or Hemiretinal Vein Occlusion. 

 

Janssen- Johnson and Johnson [Upcoming Not Yet Enrolling]

A Phase 2/3, Randomized, Double-masked, Multicenter, Dose-ranging, Sham-Controlled Clinical Trial to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
 

Upcoming Trials - Coming Soon...

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Recently Completed Trials

COOL-3 - RecensMedical Inc.

A Randomized, Masked, Controlled Trial Studying the Use of Rapid Cooling Anesthesia for Local Anesthesia among Patients Receiving Intravitreal Injections  

YOSEMITE - GR40349- Genentech Roche

A Phase III, multicenter, randomized, double-masked, active comparator controlled study to evaluate the efficacy and safety of RO6867461 in patients with diabetic macular edema.

 

TENAYA - GR40306 - Genentech Roche 

A Phase III, multicenter, randomized, double-masked, active comparator controlled study to evaluate the efficacy and safety faricimab in patients with neovascular age-related macular degeneration. 

  

COOL-3 - RecensMedical Inc 

A Randomized, Masked, Controlled Trial Studying the Use of Rapid Cooling Anesthesia for Local Anesthesia among Patients Receiving Intravitreal Injections.  

 

SCORE2 - NIH (National Eye Institute)     2014 – 2016

 Study of Comparative Treatments for Retinal Vein Occlusion 2 [SCORE2]: a multicenter, prospective, randomized non-inferiority trial of eyes with macular edema secondary to central retinal vein occlusion, comparing intravitreal bevacizumab every 4 weeks with intravitreal aflibercept every 4 weeks. 2014-2016

Other Completed Trials

  • Diabetic Retinopathy in HIV Subjects Treated with EGRIFTA

  • Treatment for center-involved DME in Eyes with Very Good Visual Acuity

  • Short-term Evaluation of Combination Corticosteroid + Anti-VEGF Treatment for Persistent Central-involved Diabetic Macular Edema Following Anti-VEGF Therapy in Pseudophakic Eyes

  • Lucentis – Avastin Trial Design

  • Protocol “L”: Evaluation of Visual Acuity Measurements in Eyes with Diabetic Macular Edema

  • Protocol “N”: An Evaluation of Intravitreal Ranibizumab for Vitreous Hemorrhage due to Proliferative Diabetic Retinopathy

  • Mild Macular Grid (MMG) for Diabetic Macular Edema

  • Steroid Injection for Diabetic Macular Edema

  • Vitrectomy for Diabetic Macular Edema

  • Peribulbar Triamcinolone

  • PRP for Diabetic Macular Edema

  • Subclinical Diabetic Macular Edema

  • Anecortave Acetate for Wet AMD

  • Anecortave Acetate for Dry AMD

  • Surgical Therapeutics for Epiretinal Membranes and Vitrectomy

  • Branch Vein Occlusion Sheathotomy Study

  • Vit 100 (VitrenAse) Study for PVR

  • Oral treatment of Diabetic Retinopathy (Lilly)

  • Photodynamic Therapy (PDT) Study – Approved by FDA 4/2000

  • Macular Translocation for CNV

  • Perfluoron (PFO) Phase IV Clinical Trial

  • Submacular Surgery Pilot Trials (SST)

  • Perfluoron Study (PFO)

  • Syntex Ganciclovir Implant Trials

  • ISIS CMV Retinitis Trials

  • RPE Transplantation Study

  • Collaborative Ocular Melanoma

  • COMS

  • Macular Photocoagulation Study (MPS)

  • IOP Vitrectomy Study

  • Age-Related Eye Disease Study

  • Richard-James Silicone Oil Study

  • Vitrectomy for Macular Hole Study

  • Endophthalmitis Vitrectomy Study (EVS)

  • Advanced ROP Study

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