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Clinical Trials

 

CURRENT TRIALS

YOSEMITE GR40349 – Genentech - Roche 

A Phase III, Multicenter, Randomized, Double-Masked, active comparator controlled study to evaluate the efficacy and safety of RO6867461 in patients with diabetic macular edema.

 

TENAYA  GR40306 – Genentech - Roche

A Phase III, Multicenter, Randomized, Double-Masked, active comparator controlled study to evaluate the efficacy and safety of FARICIMAB in patients with neovascular age related macular degeneration.

 

RAVEN – CRTH258C2302  Novartis

An Eighteen-Month, Two-Arm, Randomized, Double-Masked, Multicenter, Phase III Study Assessing the Efficacy and Safety of Brolucizumab versus Aflibercept in Adult Patients with Visual Impairment due to Macular Edema secondary to Central Retinal Vein Occlusion.

 

COMPLETED TRIALS

 HAWK - RTH258-C001   Alcon Research Ltd.

Two-Year, Randomized, Double-Masked, Multicenter, Three-Arm Study Comparing the Efficacy and Safety of RTH258 versus Aflibercept in Subjects with Neovascular Age-Related Macular Degeneration 2015-2018

 

CEDAR/SEQUIOA - AGN150998-005/006 - Allergan

Safety and Efficacy of Abicipar Pegol in Patients with Neovascular Age-related Macular Degeneration- 2016-2019

  

AERPIO - Trialrunners AKB - 9778 CI 5001 

Phase 2 Double-masked, Placebo-controlled Study To Assess The Safety And Efficacy Of Subcutaneously Administered AKB 9778 15mg Once Daily Or 15mg Twice Daily For 12 Months In Patients With Moderate To Severe Non-Proliferative Diabetic Retinopathy - 2017-2019

 

SCORE2 - NIH (National Eye Institute)     2014 – 2016

 Study of Comparative Treatments for Retinal Vein Occlusion 2 [SCORE2]: a multicenter, prospective, randomized non-inferiority trial of eyes with macular edema secondary to central retinal vein occlusion, comparing intravitreal bevacizumab every 4 weeks with intravitreal aflibercept every 4 weeks. 2014-2016

 

OTHER COMPLETED TRIALS

  • Diabetic Retinopathy in HIV Subjects Treated with EGRIFTA
  • Treatment for center-involved DME in Eyes with Very Good Visual Acuity
  • Short-term Evaluation of Combination Corticosteroid + Anti-VEGF Treatment for Persistent Central-involved Diabetic Macular Edema Following Anti-VEGF Therapy in Pseudophakic Eyes
  • Lucentis – Avastin Trial Design
  • Protocol “L”: Evaluation of Visual Acuity Measurements in Eyes with Diabetic Macular Edema
  • Protocol “N”: An Evaluation of Intravitreal Ranibizumab for Vitreous Hemorrhage due to Proliferative Diabetic Retinopathy
  • Mild Macular Grid (MMG) for Diabetic Macular Edema
  • Steroid Injection for Diabetic Macular Edema
  • Vitrectomy for Diabetic Macular Edema
  • Peribulbar Triamcinolone
  • PRP for Diabetic Macular Edema
  • Subclinical Diabetic Macular Edema
  • Anecortave Acetate for Wet AMD
  • Anecortave Acetate for Dry AMD
  • Surgical Therapeutics for Epiretinal Membranes and Vitrectomy
  • Branch Vein Occlusion Sheathotomy Study
  • Vit 100 (VitrenAse) Study for PVR
  • Oral treatment of Diabetic Retinopathy (Lilly)
  • Photodynamic Therapy (PDT) Study – Approved by FDA 4/2000
  • Macular Translocation for CNV
  • Perfluoron (PFO) Phase IV Clinical Trial
  • Submacular Surgery Pilot Trials (SST)
  • Perfluoron Study (PFO)
  • Syntex Ganciclovir Implant Trials
  • ISIS CMV Retinitis Trials
  • RPE Transplantation Study
  • Collaborative Ocular Melanoma
  • COMS
  • Macular Photocoagulation Study (MPS)
  • IOP Vitrectomy Study
  • Age-Related Eye Disease Study
  • Richard-James Silicone Oil Study
  • Vitrectomy for Macular Hole Study
  • Endophthalmitis Vitrectomy Study (EVS)
  • Advanced ROP Study